I used to suffer from this problem really badly. I think it's the type of mousemat I was using, one of those smooth surface ones that seemed to attracted dust and stuff.
Anyway, the cure for this (for me) was to get one of the new IntelliEye mice - it really is a good as the hype. I find it far more accurate, and of course doesn't need cleaning. I even threw the mouse mat away - I use a piece of card as the 'mouse mat' (glossy table srface isn't IntelliEye friendly) which is easy to replace when it gets grubby.
Give it a try.
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