Hey buddy ,... going to e-comm eh?
The answer would range vastly to what you wish to accomplish with the site, would it involve cc verification? live inventory checking? User authentication, JSP? SQL? oh.. the list is endless.
As a starter, I'd suggest checking out drumbeat, and drumbeat ultradev from macromedia, it even has a HomeSite integration version with it.
Sorry abt more questions than answers, but at least DrumBeat will help get you ask the right questions.
Cheers.
Mo