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The bigest difference is the use of the ICH5R chipset on the -E model. The P4C800 Deluxe used the ICH5 , the cheeper version without S-ATA Raid support. The -E model not only has the ICH5R chipset with the Intel S-ATA Raid on a seperate bus but it also includes a Promise 378 Fastrack chip for 2 more S-ATA drives in RAID or just normal and support for Ultra ATA 133 and below drives in a RAID setup. So you could have 6 drives in a RAID configuration on this board if you wanted
found this info, might help
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