I don't really know as if there is one that is "most compatible." Most things are distriputed as .rpm packages(Fedora/Redhat), .tgz(I think thats it, works on any system as far as I know) and also in source so you can compile it yourself. I know on Slackware there is a .rpm converter of sorts, but I don't know how well it works, and I am pretty sure they advised trying to stay with .tgz or source instead, as the conversion I imagine could be messy.
Ahhh...
here we go. That should help a lil to understand the linux packages.
I am pretty sure that as long as a package is distibuted in a compatible package format or source, and all of the dependancy's are as well, you can install any linux program on any linux system.