Spywareblaster for blocking spyware objects.
Spybot Search and Destroy and AdAware SE for scanning out anything that gets past Spywareblaster.
To stay malware free: AVG antivirus/antispyware, Malwarebytes anti malware, Commodo Pro free firewall, ccleaner, Windows updates. or....
just install Linux
Too many computers in this house to list. They are all my builds, some AMD some Intel...